Carbon-based drug delivery carriers for cancer therapy

In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug sol...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 37; no. 1; pp. 43 - 52
Main Authors Lim, Dong-Jin, Sim, Myeongbu, Oh, Leeseul, Lim, Kyunghee, Park, Hansoo
Format Journal Article
LanguageKorean
Published 2014
Subjects
Carbon nanotube
Nanodiamonds
Graphene oxide
Drug delivery
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Summary:In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.
Bibliography:KISTI1.1003/JNL.JAKO201426955812441
ISSN:0253-6269
1976-3786