Antityrosinase and antimicrobial activities from Thai medicinal plants

• Published in: Archives of pharmacal research Vol. 37; no. 4; pp. 473 - 483
• Main Authors: Dej-adisai, Sukanya, Meechai, Imron, Puripattanavong, Jindaporn, Kummee, Sopa
• Format: Journal Article
• Language: Korean
• Published: 2014
• Subjects: Antimicrobial activity; Whitening agent; Natural products; Artocarpus integer; Melanin; Antityrosinase activity
• ISSN: 0253-6269; 1976-3786

Various dermatological disorders and microbial skin infection can cause hyperpigmentation. Therefore, screenings for whitening and antimicrobial agents from Thai medicinal plants have been of research interest. Seventy-seven ethanol plant extracts were investigated for antityrosinase activity, eleven samples showed the tyrosinase inhibition more than 50 % were further preliminary screening for antimicrobial activity by agar disc diffusion and broth micro-dilution methods. Artocarpus integer (Thunb.) Merr. (Moraceae) root extract, which showed the potential of tyrosinase inhibition with $90.57{\pm}2.93%$ and antimicrobial activity against Staphylococcus aureus, S. epidermidis, Propionibacterium acnes and Trichophyton mentagophytes with inhibition zone as $9.10{\pm}0.00$, $10.67{\pm}0.09$, $15.25{\pm}0.05$ and $6.60{\pm}0.17mm$, respectively was selected for phytochemical investigation. Three pure compounds were isolated as artocarpin, cudraflavone C and artocarpanone. And artocarpanone exhibited antityrosinase effect; artocarpin and cudraflavone C also showed the potential of antibacterial activity against S. aureus, S. epidermidis and P. acnes with MIC at 2, 4 and $2{\mu}g/ml$, respectively and MBC at $32{\mu}g/ml$ for these bacteria. So, these pure compounds are interesting for further study in order to provide possibilities of new whitening and antibacterial development. This will be the first report of phytochemical investigation of A. integer root.