Neuronal Activity-Dependent Regulation of MicroRNAs

MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA reg...

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Bibliographic Details
Published inMolecules and cells Vol. 37; no. 7; pp. 511 - 517
Main Authors Sim, Su-Eon, Bakes, Joseph, Kaang, Bong-Kiun
Format Journal Article
LanguageKorean
Published 2014
Subjects
miRNA induction
neuronal activity
high-throughput screening
miRNA turnover
NMDAR
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Summary:MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may finetune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.
Bibliography:KISTI1.1003/JNL.JAKO201425560113702
ISSN:1016-8478
0219-1032