유방암세포에서 괴화 에탄올 추출물의 NF-${\kappa}B$ 의존적인 MMP-9 발현의 조절 규명을 위한 연구

• Published in: 동의생리병리학회지 Vol. 28; no. 1; pp. 22 - 28
• Main Authors: 김정미, 이영래, 황진기, 김미성, 김하림, 박연주, 유용욱, 김성철, 류도곤, 권강범, Kim, Jeong Mi, Lee, Young Rae, Hwang, Jin Ki, Kim, Mi Seong, Kim, Ha Rim, Park, Yeon Ju, You, Yong Ouk, Kim, Seong Cheol, Ryu, Do Gon, Kwon, Kang Beom
• Format: Journal Article
• Language: Korean
• Published: 2014
• Subjects: MCF-7 breast carcinoma cells; MMP-9; NF- ${\kappa}B; Invasion
• ISSN: 1738-7698; 2283-2529

Flos Sophorae, the dried flower bud of Sophora japonica L, possesses anti-inflammatory properties, prevents and treats blood capillary and hypertension diseases and can also be used as a hemostat. However, the effect of Flos Sophorae on breast cancer invasion is unknown. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix, is a major component in cancer cell invasion. In this study, we investigated the inhibitory effect of Flos Sophorae extract (FSE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced Matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in Michigan Cancer Foundation-7 (MCF-7) cells. FSE inhibited the TPA-induced transcriptional activation of nuclear factor-kappa B (NF-${\kappa}B$). These results indicate that FSE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of NF-${\kappa}B$ pathway in MCF-7 cells. Thus, FSE may have therapeutic potential for controlling breast cancer invasiveness.