Increased Expression of P2RY2, CD248 and EphB1 in Gastric Cancers from Chilean Patients

Background: Gastric cancer (GC) ranks as one of the major causes of mortality due to cancer worldwide. In Chile, it is currently the leading cause of cancer death. Identification of novel molecular markers that may help to improve disease diagnosis at early stages is imperative. Materials and Method...

Full description

Saved in:
Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 15; no. 5; pp. 1931 - 1936
Main Authors Aquea, Gisela, Bresky, Gustavo, Lancellotti, Domingo, Madariaga, Juan Andres, Zaffiri, Vittorio, Urzua, Ulises, Haberle, Sergio, Bernal, Giuliano
Format Journal Article
LanguageKorean
Published 2014
Subjects
microarray
P2RY2
CD248
EphB1
Gastric cancer
molecular markers
Online AccessGet full text

Cover

More Information
Summary:Background: Gastric cancer (GC) ranks as one of the major causes of mortality due to cancer worldwide. In Chile, it is currently the leading cause of cancer death. Identification of novel molecular markers that may help to improve disease diagnosis at early stages is imperative. Materials and Methods: Using whole-genome DNA microarrays we determined differential mRNA levels in fresh human GC samples compared to adjacent healthy mucosa from the same patients. Genes significantly overexpressed in GC were validated by RT-PCR in a group of 14 GC cases. Results: The genes CD248, NSD1, RAB17, ABCG8, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. P2RY2, Ephb1 and CD248 showed the best sensitivity for GC detection with values of 92.9%, 85.7% and 64.3% (p<0.05), respectively. Specificity was 85.7%, 71.4% and 71.4% (p<0.05), for each respectively.
Bibliography:KISTI1.1003/JNL.JAKO201418964309960
ISSN:1513-7368
2476-762X