Membrane Proteins Involved in Epithelial-Mesenchymal Transition and Tumor Invasion: Studies on TMPRSS4 and TM4SF5

The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process te...

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Bibliographic Details
Published inGenomics & informatics Vol. 12; no. 1; pp. 12 - 20
Main Authors Kim, Semi, Lee, Jung Weon
Format Journal Article
LanguageKorean
Published 2014
Subjects
membrane proteins
invasion
TMPRSS4
epithelial-mesenchymal transition
TM4SF5
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Summary:The epithelial-mesenchymal transition (EMT) is one mechanism by which cells with mesenchymal features can be generated and is a fundamental event in morphogenesis. Recently, invasion and metastasis of cancer cells from the primary tumor are now thought to be initiated by the developmental process termed the EMT, whereby epithelial cells lose cell polarity and cell-cell interactions, and gain mesenchymal phenotypes with increased migratory and invasive properties. The EMT is believed to be an important step in metastasis and is implicated in cancer progression, although the influence of the EMT in clinical specimens has been debated. This review presents the recent results of two cell surface proteins, the functions and underlying mechanisms of which have recently begun to be demonstrated, as novel regulators of the molecular networks that induce the EMT and cancer progression.
Bibliography:KISTI1.1003/JNL.JAKO201418960400865
ISSN:1598-866X
2234-0742