Mammalian RNA Granules

RNA granules such as Stress Granules (SG) and P-Bodies (PB) are aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes induced by a wide range of stresses. Over the past decade, extensive studies described key components of RNA granules, their molecular interactions and s...

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Bibliographic Details
Published inJournal of experimental & biomedical sciences Vol. 20; no. 1; pp. 1 - 7
Main Authors Jayabalan, Aravinth Kumar, Ohn, Takbum
Format Journal Article
LanguageKorean
Published 2014
Subjects
Translation initiation
Stress granules
eIF2{\alpha}$ phosphorylation
RNA binding proteins
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Summary:RNA granules such as Stress Granules (SG) and P-Bodies (PB) are aggregates of translationally stalled messenger ribonucleoprotein (mRNP) complexes induced by a wide range of stresses. Over the past decade, extensive studies described key components of RNA granules, their molecular interactions and signaling pathways require for their assembly and disassembly. However, researches defining their exact roles under stress conditions have not been performed so far, although several studies suggested their roles in neurodegenerative diseases recently. In this review, we provide an introduction about their basic properties, key components, and the dynamic nature for their assembly.
Bibliography:KISTI1.1003/JNL.JAKO201418958178598
ISSN:1738-3226
2288-7415