Real-time Detection of Trace Copper in Brain and Kidney of Fish for Medical Diagnosis

For the detection of trace copper to be used in medical diagnosis, a sensitive handmade carbon nanotube paste electrode (PE) was developed using voltammetry. Analytical optimized conditions were found at 0.05 V anodic peak current. In the same conditions, various common electrodes were compared usin...

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Published inToxicological research (Seoul) Vol. 30; no. 4; pp. 311 - 316
Main Authors Yang, Young Kyun, Pack, Eun Chul, Lee, Seung Ha, Yoo, Hai-Soo, Choi, Dal Woong, Ly, Suw Young
Format Journal Article
LanguageKorean
Published 2014
Subjects
Brain cells
Fish
Paste electrode
Copper
Kidney
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Summary:For the detection of trace copper to be used in medical diagnosis, a sensitive handmade carbon nanotube paste electrode (PE) was developed using voltammetry. Analytical optimized conditions were found at 0.05 V anodic peak current. In the same conditions, various common electrodes were compared using stripping voltammetry, and the PE was found to be more sharply sensitive than other common electrodes. At optimum conditions, the working ranges of $3{\sim}19{\mu}gL^{-1}$ were obtained. The relative standard deviation of $70.0{\mu}gL^{-1}$ was determined to be 0.117% (n = 15), and the detection limit (S/N) was found to be $0.6{\mu}gL^{-1}$ ($9.4{\times}10^{-9}M$). The results were applied in detecting copper traces in the kidney and the brain cells of fish.
Bibliography:KISTI1.1003/JNL.JAKO201402755363075
ISSN:1976-8257
2234-2753