Two New Diphenylethylenes from Arundina graminifolia and Their Cytotoxicity

Two new diphenylethylenes, gramniphenols H and I (1 and 2), together with six known diphenylethylenes (3-8), were isolated from Arundina graminifolia. The structures of 1-8 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for th...

Full description

Saved in:
Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 34; no. 11; pp. 3257 - 3260
Main Authors Li, Yin-Ke, Zhou, Bin, Ye, Yan-Qing, Du, Gang, Niu, De-Yun, Meng, Chun-Yang, Gao, Xue-Mei, Hu, Qiu-Fen
Format Journal Article
LanguageKorean
Published 2013
Subjects
Diphenylethylenes
Arundina graminifolia
Cytotoxicity
Structure elucidation
Online AccessGet full text

Cover

More Information
Summary:Two new diphenylethylenes, gramniphenols H and I (1 and 2), together with six known diphenylethylenes (3-8), were isolated from Arundina graminifolia. The structures of 1-8 were elucidated by spectroscopic methods including extensive 1D- and 2D-NMR techniques. Compounds 1 and 2 were evaluated for their cytotoxicity against five human tumor cell lines. Compound 1 showed cytotoxicity against PC3 cells with $IC_{50}$ value of 3.5 ${\mu}M$. Compound 2 showed cytotoxicity against NB4 and PC3 cells with $IC_{50}$ values of 3.6 and 3.8 ${\mu}M$, respectively.
Bibliography:KISTI1.1003/JNL.JAKO201335057740934
ISSN:0253-2964
1229-5949