Overexpression of Cyclooxygenase-1 Correlates with Poor Prognosis in Renal Cell Carcinoma

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 14; no. 6; pp. 3729 - 3734
• Main Authors: Yu, Zu-Hu, Zhang, Qiang, Wang, Ya-Dong, Chen, Jing, Jiang, Zhi-Mao, Shi, Min, Guo, Xin, Qin, Jie, Cui, Guang-Hui, Cai, Zhi-Ming, Gui, Yao-Ting, Lai, Yong-Qing
• Format: Journal Article
• Language: Korean
• Published: 2013
• Subjects: renal cell carcinoma; prognostic marker; Cyclooxygenase-1
• ISSN: 1513-7368; 2476-762X

The aim of this study was to evaluate expression of COX-1 in renal cell carcinoma (RCC) and its prognostic value. mRNA of COX-1 was detected in 42 paired RCC and adjacent normal tissues with quantitative realtime polymerase chain reaction (qRT-PCR). Expression of COX-1 was also evaluated in 196 RCC sections and 91 adjacent normal tissues with immunohistochemistry. Statistical analysis was performed to assess COX-1 expression in RCC and its prognostic significance. The results of qRT-PCR showed mRNA levels of COX-1 in RCC tissues to be significantly higher than that in adjacent normal tissues (p < 0.001). Immunohistochemical assays also revealed COX-1 to be overexpressed in RCC tissues (p < 0.001). Statistical analysis demonstrated high expression of COX-1 was correlated with tumour size (p = 0.002), pathological stage (p = 0.003), TNM stage (p = 0.003, 0.007, 0.027, respectively), and tumour recurrence (p < 0.001). Survival analysis indicated patients with high expression of COX-1 had shorter survival time (p < 0.001), and COX-1 was an independent predictor. This is the first study to reveal overexpression of COX-1 in RRC and point to use as a prognostic marker in affected patients.