Structure-Activity Relationship for Antidepressant Effect of Luteolin and Its Related Derivatives Isolated from Taraxacum mongolicum

The inhibitory effect and the structure-activity relationships of luteolin and its related derivatives isolated from Taraxacum mongolicum against MAO activities were investigated. The activity-guided isolation of extract from Taraxacum mongolicum led to the isolation of three flavonoids, luteolin, d...

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Bibliographic Details
Published inNatural product sciences Vol. 19; no. 1; pp. 8 - 14
Main Authors Hwang, Keum Hee, Lee, Nam Kyung, Kim, Gun Hee
Format Journal Article
LanguageKorean
Published 2013
Subjects
Taraxacum mongolicum
Structure-activity relationship
Luteolin derivatives
Luteolin
Monoamine oxidase inhibitor
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Summary:The inhibitory effect and the structure-activity relationships of luteolin and its related derivatives isolated from Taraxacum mongolicum against MAO activities were investigated. The activity-guided isolation of extract from Taraxacum mongolicum led to the isolation of three flavonoids, luteolin, diosmetin, and luteolin-7-glucoside, a polyphenol, chlorogenic acid, a tyrosine and a uridine. The inhibitory activities of luteolin and its related derivatives against MAOs activities are dependent on their molecular structures. The presence of the phenolic hydroxy group at para-position is the active site for MAO-A inhibition as well as of MAO-B. The methoxy group has no potential on MAO-A inhibition. An additional phenolic hydroxy group at the ortho-position alleviates about 4-fold MAO-A inhibitory activity of phenolic hydroxy group at para-position. A carboxylic group seems to be critical for DBH inhibition and has no effects on MAO.
Bibliography:KISTI1.1003/JNL.JAKO201317642692052
ISSN:1226-3907