An Efficient Synthesis of Substituted Furans by Cupric Halide-Mediated Intramolecular Halocyclization of 2-(1-Alkynyl)-2-alken-1-ones

An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 34; no. 3; pp. 887 - 891
Main Authors Fu, Wei-Jun, Xu, Feng-Juan, Guo, Wen-Bo, Zhu, Mei, Xu, Chen
Format Journal Article
LanguageKorean
Published 2013
Subjects
Copper halide
Halofurans
Cyclization
Halogenation
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Summary:An efficient synthesis of 3-halofurans by the intramolecular cyclization of 2-(1-alkynyl)-2-alken-1-ones with cupric halide has been developed. A broad range of 3-chloro- and 3-bromofuran derivatives could be obtained in the present method in moderate to good yields. The 3-halofuran derivatives are potential synthetic intermediates for amplification of molecular complexity.
Bibliography:KISTI1.1003/JNL.JAKO201314358626824
ISSN:0253-2964
1229-5949