Clinical Significance of Basal-like Breast Cancer in Chinese Women in Heilongjiang Province

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 13; no. 6; pp. 2735 - 2738
• Main Authors: Liu, Ying, Jiang, Qiu-Ying, Xin, Tao, Cai, Li, Zhao, Chang-Hong
• Format: Journal Article
• Language: Korean
• Published: 2012
• Subjects: Basal like; breast cancer; prognosis
• ISSN: 1513-7368; 2476-762X

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE- in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.