Expression of Proteasome Activator REGγ in Human Laryngeal Carcinoma and Associations with Tumor Suppressor Proteins

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 13; no. 6; pp. 2699 - 2703
• Main Authors: Li, Li-Ping, Cheng, Wei-Bo, Li, Hong, Li, Wen, Yang, Hui, Wen, Ding-Hou, Tang, Yue-Di
• Format: Journal Article
• Language: Korean
• Published: 2012
• Subjects: REG{\gamma}; laryngeal carcinoma; p21; p53
• ISSN: 1513-7368; 2476-762X

The functional significance of the proteasome activator $REG{\gamma}$ in the regulation of cell proliferation and apoptosis has been recognized. However, pathological contributions to tumor development remain to be elucidated. Both oncogenic proteins and tumor suppressors are targeted by $REG{\gamma}$ for proteasomal degradation. It has been proposed that the role of the $REG{\gamma}$ in the pathogenesis of cancer is cell- and context-specific. In this study, we aimed to explore the potential involvement of $REG{\gamma}$ in laryngeal carcinomas, comparing protein expression in tumor and adjacent tissues by immunohistochemical staining and Western blot analysis. We also characterized the correlation between the expression of $REG{\gamma}$ and the previously identified substrates p53 and p21. We showed that $REG{\gamma}$ was abnormally highly expressed in cancer tissues. Statistical analysis revealed that there was a positive relationship between the level of $REG{\gamma}$ and the expression of p53 and p21. Our study suggests that $REG{\gamma}$ overexpression can facilitate the growth of laryngeal cancer cells.