Low Microsomal Epoxide Hydrolase Expression is Associated with Bladder Carcinogenesis and Recurrence

Microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics and is associated with several forms of cancer. Here, we investigated the role of mEH expression in bladder carcinogenesis, subsequent progression and recurrence. The expression of mEH was analyzed...

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Bibliographic Details
Published inAsian Pacific journal of cancer prevention : APJCP Vol. 13; no. 2; pp. 521 - 525
Main Authors Zhang, Zhe, Yu, Xiu-Yue, Zhang, Guo-Jun, Guo, Kun-Feng, Kong, Chui-Ze
Format Journal Article
LanguageKorean
Published 2012
Subjects
recurrence
mEH
bladder carcinoma
histopathological grade
clinical stage
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Summary:Microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics and is associated with several forms of cancer. Here, we investigated the role of mEH expression in bladder carcinogenesis, subsequent progression and recurrence. The expression of mEH was analyzed by Western blot in 50 bladder urothelial carcinoma and 20 normal epithelial tissues. There was a significantly higher mEH expression in the normal epithelium (P<0.05) and mEH expression was lower in high stage than in low stage tumors (P<0.05). Further, immunohistochmistry in 106 bladder urothelial carcinoma demonstrated mEH expression to be negatively correlated with histological grade, pT stage and recurrence (P<0.05). These findings suggest the important role of mEH in bladder carcinogenesis, cancer development and recurrence, providing support for efforts to develop mEH-based gene therapy.
Bibliography:KISTI1.1003/JNL.JAKO201218552489054
ISSN:1513-7368
2476-762X