Hempseed Water Extract Ameliorates Atherosclerosis in Apolipoprotein E Knockout Mice

The principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water ext...

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Published inFood science and biotechnology Vol. 21; no. 4; pp. 927 - 932
Main Authors Seo, Jin-Hee, Jeong, Eui-Suk, Lee, Kyoung-Sun, Heo, Seung-Ho, Jeong, Dong-Gu, Lee, Sung-Joon, Kim, Eun Soo, Choi, Yang-Kyu
Format Journal Article
LanguageKorean
Published 2012
Subjects
atherosclerosis
apolipoprotein E knockout mice
hempseed
low-density lipoprotein
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Summary:The principal objective of this experiment was to evaluate the anti-atherosclerotic activity of hempseed water extract in apolipoprotein E knockout (ApoE KO) mice. Fourteen male ApoE KO mice were divided into 2 groups and were treated via intragastric inoculation for 14 weeks. The hempseed water extract (HWE) inoculation group exhibited greater gains in weight as compared to the control group, which was inoculated with distilled water. Plaque lesion areas in the aortic sinus were reduced in the HWE group. Total plasma cholesterol, LDL-cholesterol, atherosclerotic index, and cardiac risk factor were all reduced in the HWE group. These results demonstrate that HWE is an excellent nutritional resource and evidences anti-atherosclerotic activity in ApoE KO mice. Further studies will be required to assess the pharmacological mechanisms underlying these effects.
Bibliography:KISTI1.1003/JNL.JAKO201213660559435
ISSN:1226-7708
2092-6456