Fusion Between TMPRSS2 and ETS Family Members (ERG, ETV1, ETV4) in Prostate Cancers from Northern China

In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in order to explore differences in fusion rates among regions in northern and southern China, other parts of Asia, Europe, and North America...

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Published inAsian Pacific journal of cancer prevention : APJCP Vol. 13; no. 10; pp. 4935 - 4938
Main Authors Wang, Jian-Jiang, Liu, Yue-Xin, Wang, Wei, Yan, Wei, Zheng, Yu-Peng, Qiao, Lu-Dong, Liu, Dan, Chen, Shan
Format Journal Article
LanguageKorean
Published 2012
Subjects
immunity hybrid
fluorescence
gene fusion
Prostate cancer
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Summary:In this study we evaluated the frequency of fusion between TMPRSS2 and ETS family members (ERG, ETV1, ETV4) in prostate cancers in patients from northern China in order to explore differences in fusion rates among regions in northern and southern China, other parts of Asia, Europe, and North America. We examined 100 prostate cancer patients, diagnosed by means of prostate biopsy; fluorescence in situ hybridization (FISH) was used to detect the expression of TMPRSS2, ERG, ETV1 and ETV4 in cancer tissue. Differences in gene fusion rates among different ethnics groups were also analyzed. Of the 100 prostate cancer patients, 55 (55%) had the fusion gene. Among the patients with the fusion gene, 46 (83.6%) patients had the TMPRSS2:ERG fusion product, 8 (14.8%) patients had TMPRSS2:ETV1 fusion, 1 (1.6%) patient had TMPRSS2:ETV4.
Bibliography:KISTI1.1003/JNL.JAKO201205061575911
ISSN:1513-7368
2476-762X