Thirty Six Years of Research on the Selective Reduction and Hydroboration

• Published in: Bulletin of the Korean Chemical Society Vol. 32; no. 6; pp. 1808 - 1846
• Main Author: Cha, Jin-Soon
• Format: Journal Article
• Language: Korean
• Published: 2011
• Subjects: MPV type reagent; Organic functional groups; Selective reduction and hydroboration; Reducing and hydroborating agents; Aluminum and boron reagents
• ISSN: 0253-2964; 1229-5949

From 1975 to 2011, for thirty six years, the author and his collaborators have developed a variety of reducing and hydroborating agents, and applied them to organic synthesis, which involves the 1,2-reduction of ${\alpha}$,${\beta}$-unsaturated carbonyl compounds, stereoselective reduction of cycloalkanones, regioselective ring-opening of epoxides, partial reduction of carboxylic acid derivatives to aldehydes, regioselective addition to carbon-carbon multiple bonds, etc. by utilizing metal hydrides and the newly-devised the Meerwein-Ponndorf-Verley (MPV) type reagents. Such developments provide a new synthetic methodology making possible valuable selective reductions and hydroborations, not practical previously.