Anti-allergic Effect of Low Molecular Weight ${\beta}$-Glucan Prepared by ${\gamma}$-Irradiation

• Published in: Food science and biotechnology Vol. 20; no. 3; pp. 841 - 844
• Main Authors: Sung, Nak-Yun, Choi, Jong-Il, Yoon, Yo-Han, Lee, Soo-Young, Byun, Myung-Woo, Hwang, Yeoung-Jung, Koenari, Zubaidah Irawati, Lee, Ju-Woon, Kim, Jae-Hun
• Format: Journal Article
• Language: Korean
• Published: 2011
• Subjects: low molecular weight; cytokine; allergy; {\beta}$-glucan
• ISSN: 1226-7708; 2092-6456

This study evaluated the anti-allergic effect of low molecular weight ${\beta}$-glucan (25 kDa) degraded by ${\gamma}$-irradiation. Allergy was induced in mouse models administrated with ${\gamma}$-irradiated low molecular weight and non-irradiated high molecular weight ${\beta}$-glucan, respectively, for 7 days. However, only the mice treated with low molecular weight ${\beta}$-glucan had a significantly decreased the total serum IgE and ovalbumin specific-IgE levels, and significantly increased Th 1 cytokine expression compared to only allergy induced mice. The allergic responses could be reduced by low molecular weight ${\beta}$-glucan treated ${\gamma}$-irradiation through the increased expression of Th 1 response and decreased expression of total IgE and antigen specific IgE.