Antiviral Activity of Methylelaiophylin, an ${\alpha}$-Glucosidase Inhibitor

Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an ${\alpha}$-glucosidase inhibitor with an $IC_{50}$ value of 10 ${\mu}M$. It showed mixed-type inhibition of ${\alpha}$-glucosidase with a $K_i$ value of 5.94 ${\mu}M$. In addition, methylelaiophylin inhibited the intr...

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Bibliographic Details
Published inJournal of microbiology and biotechnology Vol. 21; no. 3; pp. 263 - 266
Main Authors Lee, Do-Seung, Woo, Jin-Kyu, Kim, Dong-Hern, Kim, Min-Young, Cho, So-Mi K, Kim, Jae-Hoon, Park, Se-Pill, Lee, Hyo-Yeon, Riu, Key Zung, Lee, Dong-Sun
Format Journal Article
LanguageKorean
Published 2011
Subjects
{\alpha}$-Glucosidase inhibitor
methylelaiophylin
trafficking inhibitor
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Summary:Methylelaiophylin isolated from Streptomyces melanosporofaciens was selected as an ${\alpha}$-glucosidase inhibitor with an $IC_{50}$ value of 10 ${\mu}M$. It showed mixed-type inhibition of ${\alpha}$-glucosidase with a $K_i$ value of 5.94 ${\mu}M$. In addition, methylelaiophylin inhibited the intracellular trafficking of hemagglutinin-neuramidase (HN), a glycoprotein of Newcastle disease virus (NDV), in baby hamster kidney (BHK) cells. Methylelaiophylin inhibited the cell surface expression of NDV-HN glycoprotein without significantly affecting HN glycoprotein synthesis in NDV-infected BHK cells.
Bibliography:KISTI1.1003/JNL.JAKO201106737198138
ISSN:1017-7825
1738-8872