MARCH-I: a New Regulator of Dendritic Cell Function

We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II ${\beta}$ chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC...

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Bibliographic Details
Published inMolecules and cells Vol. 29; no. 3; pp. 229 - 232
Main Authors Ishido, Satoshi, Matsuki, Yohei, Goto, Eiji, Kajikawa, Mizuho, Ohmura-Hoshino, Mari
Format Journal Article
LanguageKorean
Published 2010
Subjects
antigen presentation
E3 ubiquitin ligase
MHC class II
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Summary:We and other groups have demonstrated that the expression level of MHC class II (MHC II) is regulated through ubiquitination of the MHC II ${\beta}$ chain. We also reported that MARCH-I, an E3 ubiquitin ligase, is critical for this process. At present, however, the importance of MARCH-I-mediated MHC II regulation in vivo is still unknown. In this review, we will summarize recent advances in our understanding of MARCH-I-mediated MHC II ubiquitination, and discuss how we can overcome the difficulties inherent in these studies.
Bibliography:KISTI1.1003/JNL.JAKO201035356346186
ISSN:1016-8478
0219-1032