팔정산(八正散) 약침(藥鍼) 및 복강(腹腔) 주입 병용 시술이 글리세롤로 유발된 토끼의 급성 신부전에 미치는 영향

• Published in: Journal of pharmacopuncture Vol. 13; no. 3; pp. 73 - 80
• Main Authors: 임지연, 김민호, 이금산, 김형우, 김부여, 윤여충, 조수인, Lim, Chi-Yeon, Kim, Min-Ho, Lee, Geum-San, Kim, Hyung-Woo, Kim, Bu-Yeo, Yun, Yeo-Choong, Cho, Su-In
• Format: Journal Article
• Language: Korean
• Published: 2010
• Subjects: Pharmacopuncture; Acute Renal Failure; Paljeong-san; Peritoneal Injection
• ISSN: 2093-6966; 2234-6856

Purpose: The present study was carried out to determine if Paljeong-san extract (PJS) treatment exerts beneficial effect against the glycerol-induced acute renal failure in rabbits. Material and Method: PJS was selected in the basis of invigorating kidney which can eliminate pathogens. Rabbits were treated with PJS pharmacopuncture on Shin-shu ($BL_{23}$) point for 5 days right after the injection of 50% concentration of glycerol ($5m{\ell}/kg$ body weight). Results and Conclusions: Glycerol injection caused an increase in serum creatinine and BUN level and urine glucose secretion, which were accompanied by a reduction in GFR. PJS Pharmacopuncture treatment combined with peritoneal injection showed beneficial effect on glycerol-induced acute renal failure by inhibition of serum creatinine increase and GFR decrease.