Effect of Phellinus linteus Extract Supplementation on Cortisol and Related Cytokines in Young Male Adults

• Published in: Food science and biotechnology Vol. 19; no. 3; pp. 671 - 675
• Main Authors: Lee, Jeong-Beom, Shin, Young-Oh, Bae, Jun-Sang, Min, Young-Ki, Yang, Hun-Mo, Seo, Hyung-Seok, Kwon, Dae-Keun, Kang, Jung-Young, Song, Young-Ju
• Format: Journal Article
• Language: Korean
• Published: 2010
• Subjects: Phellinus linteus extract; cortisol; interleukin-$1{\beta}; interleukin-6
• ISSN: 1226-7708; 2092-6456

This study investigated the anti-inflammatory effects of Pellinus linteus (PL) extract supplementation in healthy young men. The subjects were 18 healthy young males 20 years of age that were given 1.5 L of 0.12% PL extract orally (n=8) or a placebo (control group, n=10) daily for 4 weeks. The body composition, the white blood cell (WBC) count and differential as well as the serum cortisol, interleukin (IL)-$1{\beta}$, and IL-6 concentrations were measured before and after the supplementation. Serum concentrations of cortisol and IL-$1{\beta}$ at rest after oral supplementation were significantly decreased compared to before treatment (p<0.01, p<0.05, respectively). However, there was no change in the IL-6. And also, these factors in PL extract supplement group were significantly reduced after performing the exercise compared to control group. These results suggest that oral PL extract supplements for 4 weeks had a significant effect on inhibition of inflammatory markers in healthy young men.