One Pot Synthesis of Substituted [1,2,4]-Triazolo [1',2':1,2]pyrimido [6,5-b]-quinoline and Its Antibacterial Activity

A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1'...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 31; no. 8; pp. 2341 - 2344
Main Authors Joshi, Ratnadeep S, Mandhane, Priyanka G, Chate, Asha V, Khan, Wajid, Gill, Charansingh H
Format Journal Article
LanguageKorean
Published 2010
Subjects
[1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline
Microwave irradiation
Antibacterial activity
SiO_2/K_2CO_3
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Summary:A convenient synthesis of substituted [1,2,4]-triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) from substituted 2-chloroquinoline-3-carbaldehyde 1(a-i) and 4H-1,2,4-triazol-3-amine 2 by using $SiO_2/K_2CO_3$ under microwave irradiation. This method affords the [1,2,4]-Triazolo [1',2':1,2]pyrimido[6,5-b]-quinoline 4(a-i) under the influence of microwave irradiation in solvent-free conditions within short span (12 - 20 min), & gaves excellent yields (89 - 95%). All the synthesized compounds were further screened for their antibacterial activities. Some of our compounds showed excellent antibacterial activities against control drugs.
Bibliography:KISTI1.1003/JNL.JAKO201026039608571
ISSN:0253-2964
1229-5949