Cherry Silver Berry (Elaeagnus multiflora) Extracts Exert Antiinflammatory Effects by Inhibiting COX-2 and Akt Signals in HT-29 Colon Cancer Cells

In this study, the potential of cherry silver berry (Elaeagnus multiflora) as a cancer preventive agent through regulating inflammatory signals including cyclooxygenase-2 (COX-2) and Akt was examined. Cherry silver berry has reported to exert anti-oxidative, anti-inflammatory, and antiproliferative...

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Bibliographic Details
Published inFood science and biotechnology Vol. 19; no. 6; pp. 1673 - 1677
Main Authors Lee, Mee-Sook, Lee, Yun-Kyoung, Park, Ock-Jin
Format Journal Article
LanguageKorean
Published 2010
Subjects
Elaeagnus multiflora
colon cancer
cyclooxygenase-2
apoptosis
Akt
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Summary:In this study, the potential of cherry silver berry (Elaeagnus multiflora) as a cancer preventive agent through regulating inflammatory signals including cyclooxygenase-2 (COX-2) and Akt was examined. Cherry silver berry has reported to exert anti-oxidative, anti-inflammatory, and antiproliferative effects. The extracts from seed and flesh of cherry silver berry were obtained, and analyzed COX-2 and Akt activities in cherry silver berry extract treated HT-29 colon cancer cells. The results showed that the treatment of seed extracts reduced cell viability at the concentrations above 1,600 mg/mL, effectively reduced COX-2 and p-Akt expression. In addition, the antiinflammatory effects seemed to be related to cancer cell death. Both of seed and flesh extracts inhibited cell growth and induced apoptosis in HT-29 cells. These results suggest that extracts of cherry silver berry may contribute to suppressing cancer growth through its anti-inflammatory and anti-proliferative effects, and natural products used as oriental medicine have the possibility to control tumor cell growth.
Bibliography:KISTI1.1003/JNL.JAKO201013351021105
ISSN:1226-7708
2092-6456