극소 저체중 출생아의 난치성 칸디다혈증에서 고용량 Caspofungin 구제요법

• Published in: Korean journal of pediatrics Vol. 53; no. 2; pp. 239 - 243
• Main Authors: 서은선, 박근화, 김성미, 정혜안, 김병국, Seo, Eun Sun, Park, Geun Hwa, Kim, Sung Mi, Jung, Hye An, Kim, Byoung Kuk
• Format: Journal Article
• Language: Korean
• Published: 2010
• Subjects: Candidiasis; Very low birth weight; Caspofungin; Infant
• ISSN: 1738-1061; 2092-7258

Candidiasis is one of the most common causes of late-onset infection among very-low-birth-weight infants (VLBW) in most neonatal intensive care units and is associated with significant morbidity and mortality. Standard therapy consists of the administration of amphotericin B, amphotericin B complex, and fluconazole. In many cases, candidiasis is not easily eradicated, despite the administration of these drugs. We report our experience of the addition of high-dose caspofungin to the conventional antifungal drugs in a VLBW infant with refractory candidemia. 저자들은 고식적인 항진균제에 반응하지 않는 극소 저체중 출생아에서 발생한 지속적인 전신 칸디다증에서 이들 고식적인 항진균제에 고용량의 caspofungin을 병용 투여하여 국내에서 처음으로 특별한 약물 부작용 없이 치유한 1례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다.