홍삼(紅蔘) 수추출물(水抽出物)이 치매조백질(痴呆蚤白質) APP 형질전환(形質轉換) 초파리에 미치는 영향(影響)

• Published in: 동의신경정신과학회지 Vol. 20; no. 1; pp. 235 - 247
• Main Authors: 김영준, 김진형, 윤종현, 정은영, 김태헌, 유영수, 강형원, Kim, Young-Jun, Kim, Jin-Heong, Yun, Jong-Hyun, Jung, Ejun-Young, Kim, Tae-Heon, Lyu, Yeong-Su, Kang, Hyung-Won
• Format: Journal Article
• Language: Korean
• Published: 2009
• Subjects: APP; Drosophila; Ginseng Radix ROOra; Alzheimer's disease; Dementia
• ISSN: 1226-6396; 2234-4942

Objectives : Ginseng Radix Rubra water extract(RGE) has been used in vivo test for its beneficial effects on neuronal survival and neuroprotective functions, particularly in connection with APP-related dementias and Alzheimer's disease (AD). APP derived from proteolytic processing of the ${\beta}$-amyloid precursor protein (APP), including the amyloid-${\beta}$ peptide (A${\beta}$), plays a critical role in the pathogenesis of Alzheimer's dementia. Methods : We determined that RGE inhibits formation of APP, which are the behavior, and possibly causative, feature of AD. Results and Conclusions : In the cells, RGE significantly activated antiapoptosis and decreased the activity of APP-grim, a key enzyme in the apoptosis cell-signaling cascade. These results suggest that neuronal damage in AD might be due to two factors: a direct APP toxicity and multiple cellular and molecular neuroprotective mechanisms, including attenuation of apoptosis and direct inhibition of APP, underlie the neuroprotective effects of RGE.