Heme Oxygenase-1 : Its Therapeutic Roles in Inflammatory Diseases

Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation,...

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Bibliographic Details
Published inImmune network Vol. 9; no. 1; pp. 12 - 19
Main Authors Pae, Hyun-Ock, Chung, Hun-Taeg
Format Journal Article
LanguageKorean
Published 2009
Subjects
mitogen-activated protein kinase
bilirubin/biliverdin
inflammation
carbon monoxide
nuclear factor E2-related factor-2
heme oxygenase-1
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Summary:Heme oxygenase (HO)-1 is an inducible enzyme that catalyzes the first and rate-limiting step in the oxidative degradation of free heme into ferrous iron, carbon monoxide (CO), and biliverdin (BV), the latter being subsequently converted into bilirubin (BR). HO-1, once expressed during inflammation, forms high concentrations of its enzymatic by-products that can influence various biological events, and this expression is proven to be associated with the resolution of inflammation. The degradation of heme by HO-1 itself, the signaling actions of CO, the antioxidant properties of BV/BR, and the sequestration of ferrous iron by ferritin all concertedly contribute to the anti-inflammatory effects of HO-1. This review focuses on the anti-inflammatory mechanisms of HO-1 actions and its roles in inflammatory diseases.
Bibliography:KISTI1.1003/JNL.JAKO200920549301053
ISSN:1598-2629
2092-6685