α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

New $\alpha$-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretat...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 30; no. 1; pp. 188 - 192
Main Authors Elbandy, Mohamed, Shinde, Pramod B, Hong, Jong-Ki, Bae, Kyung-Sook, Kim, Mi-Ae, Lee, Sang-Mong, Jung, Jee H
Format Journal Article
LanguageKorean
Published 2009
Subjects
Paecilomyces lilacinus
Pyrones
Cyclohexenones
Sponge-derived fungus
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Summary:New $\alpha$-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 ${\mu}g/mL$.
Bibliography:KISTI1.1003/JNL.JAKO200902727452241
ISSN:0253-2964
1229-5949