Polymorphic Characterization of Pharmaceutical Solids, Donepezil Hydrochloride, by 13 C CP/MAS Solid-State Nuclear Magnetic Resonance Spectroscopy

Donepezil hydrochloride is a reversible acetylcholinesterase inhibitor that is used in the treatment of Alzheimer’s disease to improve the cognitive performance. It shows different crystalline forms including hydrates. Therefore, it is very important to confirm the polymorphic forms in the formulati...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 30; no. 9; pp. 2007 - 2010
Main Authors Park, Tae-Joon, Ko, Dong-Hyun, Kim, Young-Ju, Kim, Yon-Gae
Format Journal Article
LanguageKorean
Published 2009
Subjects
Solid-state NMR
Donepezil
Pharmaceutical solids
CP/MAS
Polymorphism
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Summary:Donepezil hydrochloride is a reversible acetylcholinesterase inhibitor that is used in the treatment of Alzheimer’s disease to improve the cognitive performance. It shows different crystalline forms including hydrates. Therefore, it is very important to confirm the polymorphic forms in the formulations of pharmaceutical materials because polymorphs of the same drug often exhibit significant differences in solubility, bioavailability, processability and physical/chemical stability. In this paper, four different forms of donepezil hydrochloride were prepared and characterized using X-ray powder diffraction, Fourier transform infrared, and solid-state nuclear magnetic resonance (NMR) spectroscopy. This study showed that solid-state NMR spectroscopy is a powerful technique for obtaining structural information and the polymorphology of pharmaceutical solids.
Bibliography:KISTI1.1003/JNL.JAKO200902727191147
ISSN:0253-2964
1229-5949