Synthesis of New Imidazolyl Acetic Acid Derivatives with Anti- inflammatory and Analgesic Activities

We synthesized 2-(4-(4-fluorobenzylidene)-2-(4-fluorophenyl) 5-oxo-4,5-dihydroimidazol-1-yl) acetic acid 3. Chlorination afforded the chloro derivative 4, which reacted with different amines and hydrazine to afford compounds 5-8. Pyrazole, pyrazolone, and thiazolidinone derivatives were also synthes...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 31; no. 4; pp. 419 - 423
Main Authors Khalifa, Maha M, Abdelbaky, Nayira A
Format Journal Article
LanguageKorean
Published 2008
Subjects
pyrazole
anti-inflammatory
Imidazol-1-yl acetic acid
thiazolidinone
pyrazolone
Analgesic activity
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Summary:We synthesized 2-(4-(4-fluorobenzylidene)-2-(4-fluorophenyl) 5-oxo-4,5-dihydroimidazol-1-yl) acetic acid 3. Chlorination afforded the chloro derivative 4, which reacted with different amines and hydrazine to afford compounds 5-8. Pyrazole, pyrazolone, and thiazolidinone derivatives were also synthesized from Imidazol-1-ylacetic acid hydrazide 8 to give compounds 9-12. Compounds were then evaluated for their anti-inflammatory activity against carrageenaninduced rat paw edema and their analgesic activity using the writhing test in albino mice. Compounds 5, 9, 10, 12 exhibited maximum anti-inflammatory activity, and all the compounds inhibited writhing, with10 and 12 being two times more effective than the reference standard.
Bibliography:KISTI1.1003/JNL.JAKO200817663908149
ISSN:0253-6269
1976-3786