NCAM as a cystogenesis marker gene of PKD2 overexpression

ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-My...

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Published inBMB reports Vol. 41; no. 8; pp. 593 - 596
Main Authors Yoo, Kyung-Hyun, Lee, Tae-Young, Yang, Moon-Hee, Park, Eun-Young, Yook, Yeon-Joo, Lee, Hyo-Soo, Park, Jong-Hoon
Format Journal Article
LanguageKorean
Published 2008
Subjects
Cystogenesis
c-Myc
cDNA microarray
NACM
PKD2
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Summary:ADPKD (Autosomal Dominant Polycystic Kidney Disease) is characterized by the progressive expansion of multiple cystic lesions in the kidneys. ADPKD is caused by mutations in Ed-pl. consider PKD1 and PKD2. Recently a relation between c-myc and the pathogenesis of ADPKD was reported. In addition, c-Myc is a downstream effector of PKD1. To identify the gene regulated by PKD2 and c-Myc, we performed gene expression profiling in PKD2 and c-Myc overexpressing cells using a human 8K cDNA microarray. NCAM (neuronal cell adhesion molecule) levels were significantly reduced in PKD2 overexpressing systems in vitro and in vivo. These results suggest that NCAM is an important molecule in the cystogenesis induced by PKD2 overexpession.
Bibliography:KISTI1.1003/JNL.JAKO200810103425969
ISSN:1976-6696
1976-670X