Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the c...

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Published inBulletin of the Korean Chemical Society Vol. 29; no. 8; pp. 1472 - 1478
Main Authors Park, Hyeong-Beom, Jung, Myung-Ho, Cho, Jung-Hyuck, Oh, Chang-Hyun
Format Journal Article
LanguageKorean
Published 2008
Subjects
Substituent effects
Antibacterial activity
Spiro[2,4]heptane
1β-Methylcarbapenems
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Abstract The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.
AbstractList The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.
Author Oh, Chang-Hyun
Cho, Jung-Hyuck
Park, Hyeong-Beom
Jung, Myung-Ho
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Keywords Substituent effects
Antibacterial activity
Spiro[2,4]heptane
1β-Methylcarbapenems
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Title Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II
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