Synthesis and in vitro Activity of Novel 1β-Methylcarbapenems Having Spiro[2,4]heptane Moieties. Part II

The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the c...

Full description

Saved in:
Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 29; no. 8; pp. 1472 - 1478
Main Authors Park, Hyeong-Beom, Jung, Myung-Ho, Cho, Jung-Hyuck, Oh, Chang-Hyun
Format Journal Article
LanguageKorean
Published 2008
Subjects
Substituent effects
Antibacterial activity
Spiro[2,4]heptane
1β-Methylcarbapenems
Online AccessGet full text

Cover

More Information
Summary:The synthesis of a new series of 1$\beta$-methylcarbapenems having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents at the pyrrolidine ring was investigated. Most of the compounds were found to be more active compared to imipenem against Gram-negative bacteria. A particular compound (IIIc) having 7-oxo-5- azaspiro[2,4]heptane moiety showed the most potent antibacterial activity.
Bibliography:KISTI1.1003/JNL.JAKO200802727463413
ISSN:0253-2964
1229-5949