Observations Made in Exploring a Pyridinium Salt Photochemical Approach to the Synthesis of (+)-Lactacystin

The key step in a strategy for the synthesis of (+)-lactacystin involving photocyclization reaction of a cyclopenta-fused pyridinium salt has been probed by using a model substrate. Observations made in this effort led to the discovery of a highly unusual cascade process that leads to stereoselectiv...

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Bibliographic Details
Published inBulletin of the Korean Chemical Society Vol. 29; no. 1; pp. 89 - 93
Main Authors Zhou, Jiwen, Gong, Maozhen, Mariano, Patrick S, Yoon, Ung-Chan
Format Journal Article
LanguageKorean
Published 2008
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Summary:The key step in a strategy for the synthesis of (+)-lactacystin involving photocyclization reaction of a cyclopenta-fused pyridinium salt has been probed by using a model substrate. Observations made in this effort led to the discovery of a highly unusual cascade process that leads to stereoselective formation of an interesting tricyclic carbamate. The results of this study are presented and discussed in the context of a (+)-lactacystin synthetic approach.
Bibliography:KISTI1.1003/JNL.JAKO200802727271338
ISSN:0253-2964
1229-5949