Synthesis and Evaluation of Hydroquinone Derivatives as Inhibitors of Isocitrate Lyase
Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against I...
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| Published in | Archives of pharmacal research Vol. 30; no. 8; pp. 955 - 961 |
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| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Korean |
| Published |
2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications. |
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| AbstractList | Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications. |
| Author | Cho, Won-Jea Oh, Ki-Bong Yu, Ji-Su Kim, Sang-Hee Yang, Hyeong-Cheol Shin, Jong-Heon Shin, Dong-Sun |
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| Keywords | Hydroquinone albicans C Halisulfate Inhibitor Isocitrate lyase |
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| Title | Synthesis and Evaluation of Hydroquinone Derivatives as Inhibitors of Isocitrate Lyase |
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