Synthesis and Evaluation of Hydroquinone Derivatives as Inhibitors of Isocitrate Lyase

Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against I...

Full description

Saved in:
Bibliographic Details
Published inArchives of pharmacal research Vol. 30; no. 8; pp. 955 - 961
Main Authors Yang, Hyeong-Cheol, Yu, Ji-Su, Oh, Ki-Bong, Shin, Dong-Sun, Cho, Won-Jea, Shin, Jong-Heon, Kim, Sang-Hee
Format Journal Article
LanguageKorean
Published 2007
Subjects
Hydroquinone
albicans
C
Halisulfate
Inhibitor
Isocitrate lyase
Online AccessGet full text

Cover

More Information
Summary:Isocitrate lyase (ICL) is envisaged as an attractive drug target for the development of antimicrobial agents. We have prepared a series of hydroquinone derivatives on the basis of the structure of halisulfates, a naturally occurring inhibitor of ICL. The obtained derivatives were evaluated against ICL of C. albicans. The preliminary structure-activity relationships and the minimal structural requirements for potency were established through structural modifications.
Bibliography:KISTI1.1003/JNL.JAKO200736038098961
ISSN:0253-6269
1976-3786