Hydroxylated Hydrocinnamides as Hypocholesterolemic Agents

Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowerin...

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Published inBulletin of the Korean Chemical Society Vol. 28; no. 10; pp. 1787 - 1791
Main Authors Lee, Sang-Ku, Lee, Chul-Ho, Kim, Eung-Soo, Jung, Sang-Hun, Lee, Hyeong-Kyu
Format Journal Article
LanguageKorean
Published 2007
Subjects
Amino acid
Cinnamic acid
Hydrocinnamide
Hypocholesterolemic activity
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Summary:Several hydroxylated cinnamic acid derivatives were prepared from the corresponding acids and amino acid residues, and their hypocholesterolemic activities were evaluated in high cholesterol-fed mice. The presence of the double bond in hydroxylated cinnamide derivatives decreases cholesterol-lowering activities and the number of free phenolic hydroxy groups affect greatly the activities. 3,4-Dihydroxy hydrocinnamides obtained from amino acid derivatives containing a hydrophobic side chain such as alanine, valine, phenylalanine, and isoleucine exhibited potent cholesterol-lowering activities.
Bibliography:KISTI1.1003/JNL.JAKO200702727172733
ISSN:0253-2964
1229-5949