Anti-allodynic effect of bee venom on neuropathic pain in the rat

Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine i...

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Bibliographic Details
Published inOriental pharmacy and experimental medicine Vol. 6; no. 4; pp. 324 - 329
Main Authors Lee, Bae-Hwan, Chae, Youn-Byoung, Hwang, Hye-Jeong, Choi, Young-Kook, Hahm, Dae-Hyun, Han, Seung-Moo, Kang, Sung-Keel, Lee, Hye-Jung, Pyun, Kwang-Ho, Shim, In-Sop
Format Journal Article
LanguageKorean
Published 2006
Subjects
Bee venom
Zusanli
Morphine
Acupuncture
Neuropathic pain
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Summary:Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.
Bibliography:KISTI1.1003/JNL.JAKO200636038170622
ISSN:1598-2386
2211-1069