Central Nervous System Involvement of Acute Lymphoblastic Leukemia

Central nervous system[CNS] involvement of acute lymphoblastic leukemia may occur. However, CNS involvement as a first manifestation of leukemia is very rare. An 8-year-old girl complained of a backache after playing in the water. Neurological examination detected progressing paraparesis. Magnetic r...

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Bibliographic Details
Published inJournal of Korean Neurosurgical Society Vol. 40; no. 1; pp. 54 - 57
Main Authors Hyun, Seung-Jae, Kim, Young-Baeg, Yu, Hyeon, Hong, Hyun-Jong
Format Journal Article
LanguageKorean
Published 2006
Subjects
Spine
Leukemia
Laminectomy
Burkitt's lymphoma
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Summary:Central nervous system[CNS] involvement of acute lymphoblastic leukemia may occur. However, CNS involvement as a first manifestation of leukemia is very rare. An 8-year-old girl complained of a backache after playing in the water. Neurological examination detected progressing paraparesis. Magnetic resonance imaging[MRI] of the thoracolumbar spine showed a well-circumscribed homogeneous posterior extradural mass lesion extending from T7 to T9. MRI of the brain showed diffused fatty marrow replacement of the calvarium and the skull base. We report a patient with epidural Burkitt's lymphoma of the thoracic and lumbar vertebra causing compression of the spinal cord after pathologic evaluation. The tumor consisted mainly of lymphoblastic cells, which were identical to those originally seen in the bone marrow aspiration and biopsy. After decompressive laminectomy she began consolidation chemotherapy.
Bibliography:KISTI1.1003/JNL.JAKO200608410672444
ISSN:2005-3711
1598-7876