Transdermal Delivery of Piroxicam Using Microemulsions

To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing ef...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 28; no. 2; pp. 243 - 248
Main Authors Park Eun-Seak, Cui Yu, Yun Bum-Jin, Ko In-Ja, Chi Sang-Cheol
Format Journal Article
LanguageKorean
Published 2005
Subjects
Skin permeability
Piroxicam
Oleic acid
Phase diagram
Microemulsion
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Summary:To improve the skin permeability of piroxicam, a new oil-in-water microemulsion containing $0.5\%$ piroxicam was developed. Among various oils investigated for their suitability as an oil phase for the microemulsion system, oleic acid showed both excellent solubility and skin permeation enhancing effect for piroxicam. Microemulsion existence ranges were identified through the construction of the pseudo-ternary phase diagram. The effect of the content of oleic acid and the ratio of the surfactant/cosurfactant on skin permeation of piroxicam were evaluated with excised rat skins. The optimum formulation with the highest skin permeation rate ($47.14\;{\mu}g/cm^2/h$) consisted of $0.5\%$ piroxicam, $10\%$ oleic acid, $60\%$ Labrasol/ethanol (1:5) and water.
Bibliography:KISTI1.1003/JNL.JAKO200531935911260
ISSN:0253-6269
1976-3786