Diastereoselective Synthesis of Polysubstituted Pyrrolidinone as a Key Intermediate for the Anticancer Agents by Palladium(II)­Catalyzed Carboxylation

Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition ($K_{2}CO_3$), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and wit...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 28; no. 2; pp. 151 - 158
Main Authors Choi Dong-Rack, Lee Kee-Young, Chung Yun-Sung, Joo Jae-Eun, Kim Yong-Hyun, Oh Chang-Young, Lee Yiu-Suk, Ham Won-Hun
Format Journal Article
LanguageKorean
Published 2005
Subjects
Stereocontrol
Carboxylation
Palladium
Pyrrolidinone
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Summary:Palladium(II)-catalyzed carboxylation of chiral olefins 6a-d has been examined under various conditions. In the weak basic condition ($K_{2}CO_3$), 7a-d were obtained in good yields. Alternatively, in the strong basic condition, pyrrolidinones 8a-d were obtained resulting in excellent yields and with high diastereoselectivity.
Bibliography:KISTI1.1003/JNL.JAKO200531935910598
ISSN:0253-6269
1976-3786