고삼이 항암제 cisplatin의 췌$\cdot$심장 부작용 감소에 미치는 영향

• Published in: 동의생리병리학회지 Vol. 19; no. 4; pp. 945 - 949
• Main Authors: 김진철, 임성철, 정태영, 서정철, 한상원, Kim, Jin-Cheo, Lim, Seong-Chul, Jung, Tae-Young, Seo, Jung-Chul, Han, Sang-Won
• Format: Journal Article
• Language: Korean
• Published: 2005
• Subjects: Sophora flavescens; antitumor activities; Cisplatin
• ISSN: 1738-7698; 2283-2529

The objective of this study is to investigate the inhibitor effects of an traditional oriental herb, Sophora flavescens on the pancreatic & cardiac side effects of chemotherapy were studied by using Bl6-BL6 melanoma-injected C57BL6 mouse tumor model. In this study, the effects of an traditional oriental herb, Sophora flavescens, on the side effects of chemotherapy were studied using B16 melanoma-injected C57BL6 mouse tumor model. Anticancer drugs widely used in clinical situation. Sophora flavescen has significant effect on the reduction of the side effects of chemotherapy. Water extract of Sophora flavescens significantly inhibited cisplatin-induced increase of amylase (AMY) which is a good indicator of pancreatic toxicity. Sophora flavescens extract does not decrease the anti-tumor activity of cisplatin showing that it can selectively inhibit side effects of anticancer drugs preserving beneficial effect. Theses results suggest a possibility that Sophora flavescens extract can be used for cancer patients for the reduction of the side effects and improving the quality of life during chemotherapy of cancer patients.