Tra2${\alpha}$ and hnRNP K might be Functional Partners of Rbm for Regulation of RNA Processes during Spermatogenesis

Rbm is a male infertility gene located in the AZFb region of the Y chromosome. Expression pattern of Rbm indicates that Rbm is critical for early phase of male germ cell development. It shares strong structural homology with hnRNP G, suggesting a function as an RNA processing factor. In order to gai...

Full description

Saved in:
Bibliographic Details
Published inKorean journal of biological sciences Vol. 8; no. 1; pp. 65 - 70
Main Authors Lee, Jungmin, Kim, Euisu, Jang, Sung Key, Rhee, Kunsoo
Format Journal Article
LanguageKorean
Published 2004
Subjects
Tra2 ${\alpha}
Spermatogenesis
Male infertility
Rbm
hnRNP K
Online AccessGet full text

Cover

More Information
Summary:Rbm is a male infertility gene located in the AZFb region of the Y chromosome. Expression pattern of Rbm indicates that Rbm is critical for early phase of male germ cell development. It shares strong structural homology with hnRNP G, suggesting a function as an RNA processing factor. In order to gain a clue on the molecular mechanisms of Rbm on male germ cell development, we examined interactions of Rbm with selected proteins in yeast. The results revealed specific interactions between Rbm, hnRNP K and Tra2${\alpha}$. These results suggest that hnRNP K and Tra2${\alpha}$ may be functional partners of Rbm in male germ cells. We propose a model in which hnRNP K may playa role as a platform for Rbm and Tra2${\alpha}$.
Bibliography:KISTI1.1003/JNL.JAKO200411922999286
ISSN:1226-5071