Triterpenoid Saponin from Viola hondoensis W.Becker et H Boss. and Their Effect on MMP-1 and Type I Procollagen Expression

Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-${\beta}$-D-glucopyrano$yl-(1${\to}$2)-O-${\beta}$-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity again...

Full description

Saved in:
Bibliographic Details
Published inArchives of pharmacal research Vol. 27; no. 7; pp. 730 - 733
Main Authors Moon, Hyung-In, Chung, Jin-Ho, Lee, Joong-Ku, Zee, Ok-Pyo
Format Journal Article
LanguageKorean
Published 2004
Subjects
Viola hondoensis
Violaceae
Triterpenoid saponin
MMP1 inhibitor
Online AccessGet full text

Cover

More Information
Summary:Bioassay-guided fractionation has led to the isolation of triterpenoid saponins such as Acutoside A (3-O-[O-${\beta}$-D-glucopyrano$yl-(1${\to}$2)-O-${\beta}$-D-glucopyranosyl] oleanolic acid) from the whole plants of Viola hondoensis. Among them, Saponin 1 exhibited potent inhibitory activity against matrix metalloproteinase (MMP)-1, and prevented the UV-induced changes in the MMP-1 expression. In addition, compound was isolated from this plant for the first time.
Bibliography:KISTI1.1003/JNL.JAKO200411922633059
ISSN:0253-6269
1976-3786