Biological activity of an Indian medical plant, Indigofera cordifolia

The ethanol extract of Indigofera cordifolia was studied for in vivo gastroprotective activity, cytotoxic activity against oral tumor and normal cells, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and radical scavenging activity. The extract of I. co...

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Bibliographic Details
Published inOriental pharmacy and experimental medicine Vol. 4; no. 3; pp. 179 - 185
Main Authors Rao, Bhattiprolu Kesava, Kawase, Masami, Tanaka, Toru, Tani, Satoru, Motohashi, Noboru, Satoh, Kazue, Sakagami, Hiroshi, Terakubo, Shigemi, Nakashima, Hideki, Wolfard, Krisztina, Molnar, Joseph
Format Journal Article
LanguageKorean
Published 2004
Subjects
Anti-HIV
Indigofera cordifolia
Gastroprotective activity
MDR
Radical intensity
Cytotoxic activity
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Summary:The ethanol extract of Indigofera cordifolia was studied for in vivo gastroprotective activity, cytotoxic activity against oral tumor and normal cells, multidrug resistance (MDR) reversal activity, anti-human immunodeficiency virus (HIV) activity and radical scavenging activity. The extract of I. cordifolia showed potent gastric mucosal protective activity against stomach injury induced by HCl/EtOH solution. However, the gastroprotective activity could not be related to the radical mechanism, because the extract weakly scavenged both OH radical and $O_2*^-$. The extract also showed promising levels of MDR-reversing activity. This study demonstrates the tumor-specific cytotoxic action of the plant extract. However, the extract had no anti-HIV activity. From above results, the study suggests the medicinal importance of I. cordiforia extract.
Bibliography:KISTI1.1003/JNL.JAKO200403043175105
ISSN:1598-2386
2211-1069