랫드에서 계피유래활성물질(CB-PH)의 경구투여에 의한 4주간 반복투여독성 시험

• Published in: Journal of toxicology and public health Vol. 19; no. 4; pp. 259 - 266
• Main Authors: 조현무, 성낙원, 제정환, 박기대, 남기택, 조완섭, 한범석, 양기화, 김방현
• Format: Journal Article
• Language: Korean
• Published: 2003
• Subjects: Repeated dose toxicity; CB-PH; Rats
• ISSN: 1226-8399

Although 'Cinnamon' has been widely used for the food and biophamacy in the world, it's toxicity was not screened completely. Major component of 'cinnamon' is CB-OH and CB-PH. CB-PH has been reported to have antimutagenic effect. To investigate the toxicity of 2-o-Benzoylcinnama-Idehyde (CB-PH), repeated dose (4 weeks) oral toxicity test performed in SD rats. Results of repeated dose oral toxicity tests for 4 weeks (CB-PH; 500, 1000, 2000 mg/kg/day) suggested that the CB-PH treated group showed no significant toxicological findings with body weights, organ weights, hematological and histopathological findings. Therefore, these data indicated that the maximum tolerated dose of CB-PH was 2000 mg above/kg/day in the rats.