In Vivo Anti-Oxidant Activities of Tectochrysin

The anti-oxidant activities of tectochrysin, a major compound of propolis, were investigated. Tectochrysin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats. Tectochrysin tested exhibited a lipid peroxidation causing...

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Bibliographic Details
Published inArchives of pharmacal research Vol. 26; no. 1; pp. 43 - 46
Main Authors Lee, Sang-Hyun, Kim, Kyoung-Soon, Park, You-Mie, Shin, Kuk-Hyun, Kim, Bak-Kwang
Format Journal Article
LanguageKorean
Published 2003
Subjects
Transaminase TBA-reactant assay
Anti-oxidant enzymes
Tectochrysin
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Summary:The anti-oxidant activities of tectochrysin, a major compound of propolis, were investigated. Tectochrysin exhibited a significant decrease in serum transaminase activities elevated by hepatic damage induced by $CCl_4$-intoxication in rats. Tectochrysin tested exhibited a lipid peroxidation causing a significant decrease in MDA production in TBA-reactant assay. Tectochrysin was strong in the increase in the anti-oxidant enzymes such as hepatic cytosolic superoxide dismutase, catalase and glutathione peroxidase activities in $CCl_4$-intoxicated rats. These results suggest that tectochrysin possess not only the anti-oxidant, but also the activities in $CCl_4$-intoxicated rats. Especially, tectochrysin was found to cause significant increases in the rat liver cytosolic SOD, catalase, GSH-px activities as well as a significant decrease in the MDA production.
Bibliography:KISTI1.1003/JNL.JAKO200311922263199
ISSN:0253-6269
1976-3786