Synthetic Biology-Driven Microbial Therapeutics for Disease Treatment

The human microbiome, consisting of microorganisms that coexist symbiotically with the body, impacts health from birth. Alterations in gut microbiota driven by factors such as diet and medication can contribute to diseases beyond the gut. Synthetic biology has paved the way for engineered microbial...

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Bibliographic Details
Published inJournal of microbiology and biotechnology Vol. 34; no. 10; pp. 1947 - 1958
Main Authors Tae Hyun Kim, Byung Kwan Cho, Dae-hee Lee
Format Journal Article
LanguageKorean
Published 한국미생물생명공학회 31.10.2024
Subjects
Engineered microbial therapeutics
GI disease
infection
metabolic disease
synthetic biology
tumor
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Summary:The human microbiome, consisting of microorganisms that coexist symbiotically with the body, impacts health from birth. Alterations in gut microbiota driven by factors such as diet and medication can contribute to diseases beyond the gut. Synthetic biology has paved the way for engineered microbial therapeutics, presenting promising treatments for a variety of conditions. Using genetically encoded biosensors and dynamic regulatory tools, engineered microbes can produce and deliver therapeutic agents, detect biomarkers, and manage diseases. This review organizes engineered microbial therapeutics by disease type, emphasizing innovative strategies and recent advancements. The scope of diseases includes gastrointestinal disorders, cancers, metabolic diseases, infections, and other ailments. Synthetic biology facilitates precise targeting and regulation, improving the efficacy and safety of these therapies. With promising results in animal models, engineered microbial therapeutics provide a novel alternative to traditional treatments, heralding a transformative era in diagnostics and treatment for numerous diseases.
Bibliography:The Korean Society for Applied Microbiology
ISSN:1017-7825