5-아미노살리실산 치료를 받은 궤양성 대장염 환자에서 발생한 심낭심근염

• Published in: The Korean journal of gastroenterology Vol. 83; no. 5; pp. 197 - 199
• Main Authors: 이혜영, Hye Young Lee, 백동훈, Dong Hoon Baek
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 31.05.2024
• Subjects: 5-Aminosalicylic acid; Perimyocarditis; Ulcerative colitis
• ISSN: 1598-9992

5-Aminosalicylic acid (5-ASA) is recommended for managing ulcerative colitis. Common adverse effects associated with 5-ASA include gastrointestinal disorders, headaches, and skin rashes. Perimyocarditis induced by 5-ASA is a rare adverse effect, with only a limited number of cases reported. This paper presents a case of 5-ASA-induced perimyocarditis in a 29-year-old female who had been taking 5-ASA for three weeks. The patient was admitted to the emergency department with dyspnea, chest discomfort, and fever. She subsequently underwent laboratory investigations, including electrocardiography, transthoracic echocardiography, chest computed tomographic angiography, cardiac magnetic resonance imaging, and heart biopsy. Intravenous steroid was administered, and 5-ASA was discontinued. The patient’s signs and symptoms improved significantly within a few days of discontinuing 5-ASA, leading to her subsequent discharge. This case highlights the importance of considering perimyocarditis in patients exhibiting cardiac symptoms during 5-ASA therapy, despite it being a rare adverse effect. Drug withdrawal in such cases may lead to rapid clinical improvement. (Korean J Gastroenterol 2024;83:197-199)